Poypharmacy side-effect association network

Dataset information

This is a network of polypharmacy side-effects. Nodes represent drugs and edges represent different types of side effects that are associated with drug pairs. Edges indicate which side effects a patient will likely experience if he takes two drugs together (i.e., a drug combination). Such side effects are known as polypharmacy side-effects, as they are associated with drug pairs (or higher-order drug combinations) and cannot be attributed to either individual drug in the pair (in a drug combination).

Polypharmacy side-effect information was generated based on national adverse event reporting systems.

References

• Modeling polypharmacy side effects with graph convolutional networks. Marinka Zitnik, Monica Agrawal, and Jure Leskovec. Bioinformatics. 2018.
  Presented at ISMB 2018

• Data-driven prediction of drug effects and interactions. Tatonetti, Nicholas P., et al. Science Translational Medicine. 2012.
  

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