Tissue-specific protein-protein interaction network

Dataset information

This is a collection of physical protein-protein interaction networks for a large number of human tissues. Nodes represent human proteins and edges represent tissue-specific physical interactions between proteins.

The information is based on physical protein-protein interactions supported by experimental evidence. Interactions based on gene expression and evolutionary data are not considered. Tissue-specific networks are constructed based on a global (i.e., tissue-nonspecific) network. Given a human tissue, every interaction in the global network is labeled as specifically co-expressed in that tissue. An interaction is specifically co-expressed if either both proteins are specific to that tissue or one protein is tissue-specific and the other is ubiquitous. Finally, a protein-protein interaction network specific to the tissue is a subnetwork of the global network, induced by specifically co-expressed interactions.

References

• Predicting multicellular function through multi-layer tissue networks. Marinka Zitnik and Jure Leskovec. Bioinformatics. 2017.
  

• Understanding multicellular function and disease with human tissue-specific networks. Greene, Casey S., et al. Nature Genetics. 2015.
  

• BRENDA in 2015: exciting developments in its 25th year of existence. Chang, Antje, et al. Nucleic Acids Research. 2014.
  

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