Drug-drug interaction network

Dataset information

This is a network of interactions betweeen drugs, which are approved by the U.S. Food and Drug Administration. Nodes represent drugs and edges represent drug interactions. Drug-drug interactions occur when the pharmacologic effect of a one drug is altered by the action of another drug, leading to unpredictable clinical effects such as adverse drug reactions. When several drugs are administered together, there might be a greater possibility of adverse drug reactions as one drug can increase or decrease the effect of another drug. It is thus crucial to identify drug-drug interactions, especially during drug development, when one needs to identify interactions between a new candidate drug and drugs that are already on the market.

Drug-drug interactions are extracted from drug labels and scientific publications.

References

• DrugBank 5.0: a major update to the DrugBank database for 2018. Wishart, David S., et al. Nucleic Acids Research. 2017.
  

• MINER: Gigascale multimodal biological network. Stanford SNAP Group. GitHub Repository. 2017.
  

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